Practice Questions CLINICAL PHARMACY
1. In a zero order elimination process, which of the following is true?A. The removal of drug is independent of drug concentration
B. Cl = Elimination rate/Cp
C. t1/2 = .7VD/Cl
D. All are true
B. Cl = Elimination rate/Cp
C. t1/2 = .7VD/Cl
D. All are true
A. Excretion rate
B. Metabolism rate
C. Absorption rate
D. Distribution rate
E. All of the above
B. Metabolism rate
C. Absorption rate
D. Distribution rate
E. All of the above
A. Excretion
B. Elimination
C. Extraction Ratio
D. Enterohepatic Recycling
B. Elimination
C. Extraction Ratio
D. Enterohepatic Recycling
A. Cl = Elimination rate/Cp
B. Cl = QxE
C. Cl = .7VD/t1/2
D. All are correct
B. Cl = QxE
C. Cl = .7VD/t1/2
D. All are correct
A. 24mg
B. 0.24 mg
C. 2.4 mg
D. 4.1 mg
B. 0.24 mg
C. 2.4 mg
D. 4.1 mg
A. 5 mg
B. 2.5 mg
C. 1.25 mg
D. 625 mg
B. 2.5 mg
C. 1.25 mg
D. 625 mg
A. 30 L/hr/70 Kg
B. 60 L/hr/70 Kg
C. 120 L/hr/70 Kg
D. 250 L/hr/70 Kg
B. 60 L/hr/70 Kg
C. 120 L/hr/70 Kg
D. 250 L/hr/70 Kg
A. Glucuronyl transferase
B. Sulfotransferase
C. Glutathione transferase
D. a & b
E. All of the above
B. Sulfotransferase
C. Glutathione transferase
D. a & b
E. All of the above
A. CYP1A2
B. CYP2C9
C. CYP3A4
D. CYP51
E. All are drug metabolizing isoforms
B. CYP2C9
C. CYP3A4
D. CYP51
E. All are drug metabolizing isoforms
A. CYP1A2
B. CYP2C9
C. CYP2D6
D. CYP3A4
E. CYP51
B. CYP2C9
C. CYP2D6
D. CYP3A4
E. CYP51
A. Cytochrome P450
B. Alcohol Dehydrogenase
C. Glucuronyl Transferase
D. Sulfotransferase
E. All of the above
B. Alcohol Dehydrogenase
C. Glucuronyl Transferase
D. Sulfotransferase
E. All of the above
A. Both add oxygen from O2 to substrates and also form water
B. Both carry out direct heteroatom oxidations
C. Both carry out oxidative deaminations
D. Both carry out N-dealkylations
E. All of the above
B. Both carry out direct heteroatom oxidations
C. Both carry out oxidative deaminations
D. Both carry out N-dealkylations
E. All of the above
A. Ester hydrolysis
B. N-oxidation
C. Glucuronide conjugation
D. a & b
B. N-oxidation
C. Glucuronide conjugation
D. a & b
E. All of the above
A. Hydroxylation
B. Glucuronidation
C. Sulfation
D. Glutathione conjugation
B. Glucuronidation
C. Sulfation
D. Glutathione conjugation
A. No change
B. Increase
C. Decrease
B. Increase
C. Decrease
Answer Key
1. A
2. A
3. C
4. D
5. C
6. C
7. A
8. D
9. D
10. E
11. E
12. C
13. C
14. A
15. C
1. A
2. A
3. C
4. D
5. C
6. C
7. A
8. D
9. D
10. E
11. E
12. C
13. C
14. A
15. C
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